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KMID : 0438219750120010235
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Korea University Medical Journal
1975 Volume.12 No. 1 p.235 ~ p.250
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Mitotic Activity of Gastrointestinal Mucosa after Starvation in Vitamin E Injected Mouse
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Abstract
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To access the effects of vitamin E and starvation on the gastrointestinal tract, mitotic rate and cell number constituting intestinal crypt were studied. Vitamin E was administered on a daily dose of 5mg; 10 days and 20 days, while another groups of mice were injected with physiological saline solution. Mitotic index and cell number per crypt of duodenum and colon were calculated at the periods of starvation; 24, 48, 72 hours and at the time of death.
1. Starvation definitely caused a reduction in the rate of mitosis; decline went with fasting period. The mitotic index was decreased average 48.60% in the stomach, 57.39% in the duodenum, and 56.40 % in the colon at the end of starvation.
2. Epithelial cell lining the crypt of duodenum showed most frequent mitosis and reduction of the mitotic rate occurred greater degree until 48-hour starvation, after that decline of mitotic index went moderately to end.
3. In general, the injection of vitamin E for 10 days and free access of water groups showed the tendency of increased mitotic rate. However, the value of the final groups indicated no differences with controls because of the longer survival time.
4. Following starvation there is a significant reduction in the number of epithelial cell lining the duodenum. In the villi decreases were average 24.80% at the end of survival, while crypt showed less degree of reduction (14.04%)
5. It seems the number of epithelial cells per crypt of colon decreased due to starvation, however, it showed different tendency in compare with those of the duodenum. It means the number of decrease was not proportion to the starvation proceed and showed irregular patterns. Among these the saline injection groups indicated the superiority in number at all times through the observation.
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KEYWORD
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